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Cat No. | Product Name | Synonyms | Targets |
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T4309 | CIL56 | CA3 | Ferroptosis , ROS |
CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyuns... | |||
T9027 | CA-4948 | Emavusertib | IRAK , FLT |
CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity. | |||
T2782 | Catharanthine | (+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine | Calcium Channel , AChR |
Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM). | |||
T6212 | Combretastatin A4 | CA4,CRC 87-09 | Microtubule Associated |
Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). | |||
T40376 | L-Phenylalanine-15N | (S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N | Calcium Channel |
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) is the 15N-labeled L-Phenylalanine. L-Phenylalanine is an essential amino acid isolated from Escherichia coli . L-Phenylalanine is a α2δ subunit of voltage-dep... | |||
T3377 | L-Phenylalanine | (S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine | Calcium Channel , Endogenous Metabolite , iGluR |
L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels. | |||
T3915 | Ginsenoside Ro | Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V | Calcium Channel , Reductase , Prostaglandin Receptor |
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM. | |||
T1260 | Cromolyn sodium | Disodium Cromoglycate,FPL 670 (Cromolyn) Disodium,FPL-670,Sodium cromoglycate | Others , Potassium Channel , GSK-3 , Calcium Channel |
Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. | |||
T7550 | Barnidipine | YM-09730-5(Free base),Mepirodipine | Calcium Channel |
Barnidipine (YM-09730-5(Free base)) is a calcium channel blocker. | |||
T16564 | PPADS tetrasodium | P2X Receptor , Na+/Ca2+ Exchanger | |
PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma in... | |||
T4S1419 | (±)-Praeruptorin A | Praeruptorin A,(-)-Praeruptorin A | p38 MAPK , Calcium Channel , Akt |
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ... | |||
T2S2215 | Crebanine | Apoptosis , Others , Akt | |
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat... | |||
T6S2140 | β-Anhydroicaritin | Anhydroicaritin,Beta-Anhydroicaritin | MMP , Others , TNF , Interleukin |
1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical ... | |||
T4S2326 | Cornuside | 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside | ERK , p38 MAPK , NF-κB , JNK |
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi... | |||
T67775 | Enpp/Carbonic anhydrase-IN-1 | PDE , Carbonic Anhydrase | |
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectiv... | |||
T61340 | CAII-IN-3 | ||
CAII-IN-3 (compound 3h) is a thiosemicarbazone derivative known for its potent inhibition of carbonic anhydrase-II (CA-II). It exhibits an IC50 value of 13.4 μM [1]. | |||
T63753 | HCAIX-IN-3 | ||
hCAII-IN-3 (compound 7e) is a selective and potent carbonic anhydrase (CA II/IX) inhibitors with their Kis values of 124.2 and 30.5 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease. | |||
T31573 | DPX-3778 | ||
DPX-3778 is the triethanolamine salt of 3-(p-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H) dione, at concentrations of 0.124-2.48 μM enhanced ca. 4-5-fold the proliferation of tobacco (Nicotiana tabacum L. cv. Wisconsin ... | |||
T23102 | OBAA | Others | |
OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3]. | |||
T75866 | RFRP-3(human) TFA | ||
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human homolog of the GnIH peptide, significantly suppresses gonadotropin release through inhibition of Ca 2+ mobilization. Acting as an NPFF1 receptor agonist, RFRP-3 (huma... |